From knowledge to effect
SolidarMed places great importance on the impact of its programs. Therefore, the latest scientific findings from the field of global health flow into projects for our beneficiaries. Thanks to targeted quality control, treatments are continuously improved.
Together with academic partners, SolidarMed also contributes to scientific exchange. The schematic illustration shows SolidarMed's efforts in the field of HIV/AIDS over the last 10 years.
Niklaus D. Labhardt et al. (2012): Adoption of new HIV treatment guidelines and drug substitutions within first-line as a measure of quality of care in rural Lesotho: health centers and hospitals compared, Tropical Medicine and International Health.
Niklaus Daniel Labhardt et al. (2016): Same day ART initiation versus clinic-based pre-ART assessment and counselling for individuals newly tested HIV-positive during community-based HIV testing in rural Lesotho – a randomized controlled trial (CASCADE trial), BMC Public Health.
Niklaus D. Labhardt et al. (2016): Should viral load thresholds be lowered?: Revisiting the WHO definition for virologic failure in patients on antiretroviral therapy in resource-limited settings, Medicine.
Niklaus Daniel Labhardt et al. (2017): Metabolic syndrome in patients on first-line antiretroviral therapy containing zidovudine or tenofovir in rural Lesotho, Southern Africa, Tropical Medicine and International Health.
Niklaus Daniel Labhardt et al. (2017): When patients fail UNAIDS’ last 90 - the “failure cascade” beyond 90-90-90 in rural Lesotho, Southern Africa: a prospective cohort study, Journal of the International AIDS Society.
Niklaus D. Labhardt et al. (2018): Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho The CASCADE Randomized Clinical Trial, JAMA.
Alain Amstutz et al.(2018): SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on firstline ART with viremia below 1000 copies/ mL: protocol of a multicenter, parallelgroup, open-label, randomized clinical trial in Lesotho, Southern Africa, BMC Infectious Diseases.
Panayidou, Klea et al. (2018): Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation, Journal of the International AIDS Society.
Glass TR et al. (2019): The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho, PLoS ONE.
Priscilla R Tsondai et al. (2020): Characterizing the double-sided cascade of care for adolescents living with HIV transitioning to adulthood across Southern Africa, Journal of the International AIDS Society.
Alain Amstutz et al. (2020): Engagement in Care, Viral Suppression, Drug Resistance, and Reasons for Nonengagement After Home-Based Same-Day Antiretroviral Therapy Initiation in Lesotho: A Two-Year Follow-up of the CASCADE Trial, Clinical Infectious Diseases.
Alain Amstutz et al. (2020): Low rates of active hepatitis B and C infections among adults and children living with HIV and taking antiretroviral therapy: a multicenter screening study in Lesotho, J Med Virol.
Thabo Ishmael Lejone et al. (2020): PEBRA trial – effect of a peer-educator coordinated preference-based ART service delivery model on viral suppression among adolescents and young adults living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho, BMC Public Health.
Alain Amstutz et al. (2020): Home-based oral self-testing for absent and declining individuals during a door-to-door HIV testing campaign in rural Lesotho (HOSENG): a cluster-randomised trial, Lancet HIV.
Brown JA et al. (2020): Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania, BMC.
Amstutz A et al. (2020): Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: An open-label randomized controlled trial in Lesotho, PLOS Med.
Amstutz A et al. (2020): "If it is left, it becomes easy for me to get tested": Use of oral self-tests and community health workers to maximize the potential of home-based HIV testing among adolescents in Lesotho, J Int AIDS Soc.