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From knowledge to effect

05.05.2021

SolidarMed places great importance on the impact of its programs. Therefore, the latest scientific findings from the field of global health flow into projects for our beneficiaries. Thanks to targeted quality control, treatments are continuously improved.

The full illustration of how scientific influences shape SolidarMed's projects is available for download in the following section.

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Together with academic partners, SolidarMed also contributes to scientific exchange. The schematic illustration shows SolidarMed's efforts in the field of HIV/AIDS over the last 10 years.

HIV treatment in hospitals alone does not reach many people.

Tests are performed during home visits. If the result is positive, patients can start treatment without delay and on site.

A school girl shows off her finger prick. In remote mountain villages, SolidarMed tests people for HIV and offers immediate treatment.

Scientific references

Alain Amstutz et al. (2020): Low rates of active hepatitis B and C infections among adults and children living with HIV and taking antiretroviral therapy: a multicenter screening study in Lesotho, J Med Virol. 

Alain Amstutz et al. (2020): Engagement in Care, Viral Suppression, Drug Resistance, and Reasons for Nonengagement After Home-Based Same-Day Antiretroviral Therapy Initiation in Lesotho: A Two-Year Follow-up of the CASCADE Trial, Clinical Infectious Diseases.

Alain Amstutz et al. (2020): Home-based oral self-testing for absent and declining individuals during a door-to-door HIV testing campaign in rural Lesotho (HOSENG): a cluster-randomised trial, Lancet HIV. 

Alain Amstutz et al. (2020): Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: An open-label randomized controlled trial in Lesotho, PLOS Med.

Alain Amstutz et al. (2020): "If it is left, it becomes easy for me to get tested": Use of oral self-tests and community health workers to maximize the potential of home-based HIV testing among adolescents in Lesotho, J Int AIDS Soc.

Alain Amstutz et al.(2018): SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on firstline ART with viremia below 1000 copies/ mL: protocol of a multicenter, parallelgroup, open-label, randomized clinical trial in Lesotho, Southern Africa, BMC Infectious Diseases.

N. Anderegg et al. (2020): Loss to follow-up correction increased mortality estimates in HIV-positive people on antiretroviral therapy in Mozambique, J Clin Epidemiol. 

JA Brown et al. (2020): Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania, BMC. 

B. Chi et al. (2011): Universal definition of loss to follow-up in HIV treatment programs: a statistical analysis of 111 facilities in Africa, Asia, and Latin America, PLoS Med.

Jochen Ehmer (2013): Why we should combat HIV stronger and differently, Medicus Mundi Bulletin #129.

N. Ford et al. (2020): Emerging priorities for HIV service delivery, PLOS Med.

Thomas Gass (2014): Reasons for non-adherence, treatment interruption and loss to follow-up in a decentralised antiretroviral treatment programme in rural Zimbabwe, Doctoral Thesis. 

TR Glass et al. (2019): The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho, PLoS ONE. 

Thomas Gsponer et al. (2012): Variability of Growth in Children Starting Antiretroviral Treatment in Southern Africa, Paediatrics.

Jonas Hector, et al. (2018): No Impact of Hepatitis B Virus Infection on Early Mortality among HIV-infected patients in Southern Africa, CID.

Jonas Hector et al. (2018): Acceptability and performance of a directly assisted oral HIV self-testing intervention in adolescents in rural Mozambique, PLOS ONE. 

MA Hobbins et al. (2009): The human sperm, Medicu Mundi Bulletin #113.

Niklaus D. Labhardt et al. (2019): Effect and cost of two successive home visits to increase HIV testing coverage: a prospective study in Lesotho, Southern Africa, BMC Public Health.

Niklaus D. Labhardt et al. (2018): Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho The CASCADE Randomized Clinical Trial, JAMA.

Niklaus D. Labhardt et al. (2017): Metabolic syndrome in patients on first-line antiretroviral therapy containing zidovudine or tenofovir in rural Lesotho, Southern Africa, Tropical Medicine and International Health.

Niklaus D. Labhardt et al. (2017): When patients fail UNAIDS’ last 90 - the “failure cascade” beyond 90-90-90 in rural Lesotho, Southern Africa: a prospective cohort study, Journal of the International AIDS Society.

Niklaus D. Labhardt et al. (2016): Same day ART initiation versus clinic-based pre-ART assessment and counselling for individuals newly tested HIV-positive during community-based HIV testing in rural Lesotho – a randomized controlled trial (CASCADE trial), BMC Public Health.

Niklaus D. Labhardt et al. (2016): Should viral load thresholds be lowered?: Revisiting the WHO definition for virologic failure in patients on antiretroviral therapy in resource-limited settings, Medicine.

Niklaus D. Labhardt et al. (2015): Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings?, Tropical Medicine and International Healthz.

Niklaus D. Labhardt et al. (2014): Home-Based Versus Mobile Clinic HIV Testing and Counselling in Rural Lesotho: A Cluster Randomized Trial, PLoS Medicine.

Niklaus D. Labhardt et al. (2013): Outcomes of Antiretroviral Treatment Programs in Rural Lesotho: Health Centres and Hospitals Compared, Journal of the International Aids Society (JIAS).

Niklaus D. Labhardt et al. (2012): A Clinical Prediction Score in Addition to WHO Criteria for Anti-Retroviral Treatment Failure in Resource-Limited Settings - Experience from Lesotho, PLoS ONE. 

Niklaus D. Labhardt et al. (2012): Adoption of new HIV treatment guidelines and drug substitutions within first-line as a measure of quality of care in rural Lesotho: health centers and hospitals compared, Tropical Medicine and International Health. 

Thabo Ishmael Lejone et al. (2020): PEBRA trial – effect of a peer-educator coordinated preference-based ART service delivery model on viral suppression among adolescents and young adults living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho, BMC Public Health. 

Klea Panayidou et al. (2018): Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation, Journal of the International AIDS Society. 

Daniel Puga et al. (2016): Still Far From 90-90-90: Virologic Outcomes of Children on Antiretroviral Therapy in Nurse-led Clinics in Rural Lesotho, Pediatr Infect Dis J. 

The IeDEA and ART cohort collaborations (2015): Immunodeficiency at the start of combination antiretroviral therapy in low, middle and high income countries, J Acquir Immune Defic Syndr. 

Priscilla R Tsondai et al. (2020): Characterizing the double-sided cascade of care for adolescents living with HIV transitioning to adulthood across Southern Africa, Journal of the International AIDS Society.

Priscilla R Tsondai et al. (2020): Characteristics and outcomes of adolescents living with perinatally acquired HIV within Southern Africa, AIDS. 

Gilles Wandeler et al. (2016): Hepatitis B Infection, Viral Load and Resistance in HIV-Infected Patients in Mozambique and Zambia, PLoS ONE.

Gilles Wandeler et al. (2016): Absence of Active Hepatitis C virus infection in HIV clinics in Zambia and Mozambique, Open Forum Infectious Diseases.

Gilles Wandeler et al. (2013): AZT impairs immunological recovery on first-line ART: collaborative analysis of cohort studies in Southern Africa, Journal AIDS. 

Gilles Wandeler et al. (2012): Outcomes of antiretroviral treatment programs in rural Southern Africa, Journal AIDS.

Elizabeth Zaniewski et al. (2020): Trends in CD4 and viral load testing 2005 to 2018: multi-cohort study of people living with HIV in Southern Africa, Journal of the International AIDS Society. 

Academic partners

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Swiss TPH | University of Basel

Swiss Tropical and Public Health Institute

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Institute for Social and Preventive Medicine | University of Bern

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Inselspital Bern

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International epidemiology Databases to Evaluate AIDS

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“We can’t afford to give up the fight against AIDS"

Forty-one-year-old Kuda Madzeke has been SolidarMed Country Director in Zimbabwe since October 2021 and is responsible for the implementation of all projects in that country. He sat down with us to talk about what has to be done in the fight against AIDS and about his vision for SolidarMed.

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